Sr. Director, Translational Pharmacology
Company: NeuroTech X
Location: Seattle
Posted on: May 2, 2024
Job Description:
Sr. Director, Translational Pharmacology
Drug Discovery - Seattle, WA - Full time
Sr. Director, Translational Pharmacology
Seattle, WA
Job Description.
Cajal is seeking a Sr. Director, Translational Pharmacology,
motivated by Cajal's mission to develop new medicines for patients
suffering with neurodegenerative disorders. We are a
multi-disciplinary team of experienced scientists, combining
state-of-the-art approaches in computational biology, functional
genomics, high-throughput imaging, translational models, and drug
discovery. In a short time, we have assembled a terrific team of
talented, innovative, and passionate individuals to transform the
field of neurodegeneration drug discovery. Cajal is now expanding
to establish a world-class drug discovery organization.
The Sr. Dir./VP, Translational Pharmacology will leadin vitroandin
vivopharmacology efforts to discover and progress novel therapeutic
molecules for neurodegenerative diseases. The position requires
direct management of pharmacology scientists as well as serving as
project team leader for 1-2 preclinical stage drug discovery teams.
Productive management of both internal scientific resources and
external collaborators and contractors is required, as well as
effective and generous collaborations across multiple departments
within Cajal.
Responsibilities
- Lead 1-2 drug discovery program core teams, responsible for
creating the program strategy and implementing nimble,
cost-effective tactics to deliver on that strategy. The core team
leader is accountable for coordinating a matrixed team of subject
matter experts working to rapidly progress preclinical therapeutic
programs while delivering deeper mechanistic insights into the
underlying biology. Teams may include external contract-research
drug discovery teams as well as internal scientists and part-time
consultants.
- Strategically select biochemical, cellular andin
vivopharmacology assays and prioritize the development and use of
those assays to provide actionable data in support of drug
discovery and development programs for neurodegenerative disease
therapeutics.
- Lead focused pharmacology teams (in vitroandin vivo) to
efficiently screen and thoroughly characterize novel small
molecules and antisense oligonucleotides in appropriate cellular
and rodent models.
- Accountable for the quality of the teams' output, leading
experts to generate and document high quality, trusted and accurate
data.
- Provide a framework for the team to make clear, rapid decisions
and recommendations after thorough scientific and strategic
discussion.
- Anticipate risks and barriers to success and proactively seeks
solutions, resources and options that reduce those issues and their
impacts.
- Author reports and pharmacology sections of important
nonclinical regulatory documents, including INDs, CTAs,
investigator brochures, etc.
- Build strong and productive collaborations across scientific
functions at Cajal, including target discovery, computational
biology, translational models, translational biomarkers, chemistry,
DMPK, and clinical science.
- Maintain a deep and current knowledge of advances in the field,
with a particular focus on emerging technologies for the
development of human cellular models and human-relevant animal
models and endpoints.
- Engage as needed with external partners and consultants to
support efficient, data-driven decision making.
- Contribute to assessing and prioritizing relevant capital
expenses and outside services contracts.
- Write peer-reviewed publications and prepare presentations
internally and for relevant conferences.
This job might be great for you if you have:
- Ph.D. in the field of neuroscience or pharmacology, with at
least 8 years of industry experience in drug discovery or
development for CNS diseases.
- Demonstrated experience leading drug discovery teams from
discovery through IND, including strategic planning, risk analysis,
decision-making, and prioritization. Experience with a variety of
targets and modalities is valuable.
- Deep knowledge of pharmacology, disease-related neuroscience,
and emerging techniques in the use of cellular and animal models of
drug discovery.
- Familiarity with other drug discovery disciplines, including
chemistry, DMPK, proteomics, lipidomics, toxicology and clinical
pharmacology, and the ability to confidently lead or participate in
technically complex cross-functional discussions.
- Experience managing a small, focused lab-based team of
biologists and pharmacologists.
- Experience interacting with contract research organizations,
including study design and management, budgeting, report reviews,
and effectively leading communication across the
organization.
- Demonstrated ability to contribute to IND-enabling data
preparation, including data generation, data interpretation, and
review and reporting of nonclinical data.
- Knowledge of FDA, EMA/ICH regulations and requirements for GLP
preclinical study design and documentation.
- Excellent interpersonal, written and oral communication
skills.
- A disposition to be very science- and data-driven,
detail-oriented and thrive in a highly collaborative, fast-paced,
team-oriented startup environment.
Important Considerations
- Cajal operates as a hybrid workplace, but we prefer that team
members spend part of their time working on-site in our Seattle
offices.
- Please note, this opportunityoffersrelocation
assistance.
- The annual base salary range for this role is
$225,000-$250,000
*Final salary depends on qualifications, experience, and level of
skills relevant to the role, along with location, where
applicable.
Company & Benefits
Cajal is a team of people first, motivated by our shared mission to
advance the field of neurodegeneration. We are committed to
ensuring that all our team members feel supported, connected, and
energized at work. Our team members eagerly navigate the
uncertainty and fast-paced environment of an early-stage biotech
company and thrive on getting things done. We value creativity and
curiosity in our work, and we take pride in the generosity,
sincerity, and kindness of our team members.
Benefits include:
- Competitive compensation based on experience level
- Health insurance: 100% coverage of premiums for employee,
partner, & all dependents
- Dental insurance: 100% of premiums
- Vision insurance: 100% of premiums
- Life insurance: 100% of premiums for 2x salary
coverage
- Access to Flexible Spending Account
- 401(K) Plan with matching contributions
- 5 weeks paid time off plus 13 company holidays (2
floating)
- 8 weeks parental leave for primary caregiver or 4 weeks for
secondary caregiver in addition to WA Paid Family & Medical Leave
(up to 12 additional weeks)
- Generous commuter benefits including free metro cards, on site
locker rooms/showers/towel service, modern bike cage and free bike
tunes
Located in the Eastlake neighborhood of Seattle, Cajal sits at the
heart of a vibrant biotech community, directly between research
giants such as the Allen Institute and the Fred Hutchinson Cancer
Center. We are surrounded by fellow innovative biotech companies
and startups and within a stone's throw of the beautiful Lake Union
and the University of Washington. Our newly renovated office and
labs offer ample natural light and stunning views of the Space
Needle downtown. Our kitchen is fully stocked with coffee, tea, and
snacks. All desks are sit-stand for maximal comfort and our meeting
rooms seamlessly support hybrid teams.
Cajal is an equal opportunity employer that guarantees a work
environment that respects and values diversity at our company. We
do not discriminate on the basis of race, religion, color, national
origin, sex, gender, gender expression, sexual orientation, age,
marital status, veteran status, or disability status. If you
require any accommodations during the recruiting process, please
coordinate with your recruiting contact.
To the extent permitted by applicable law, employment is
conditioned upon full vaccination (per CDC guidelines) from the
COVID-19 virus, including submission of documented proof thereof,
as of the start date. Cajal will comply with applicable law
regarding the reasonable accommodation of individuals who are not
vaccinated because of a disability and/or sincerely held religious
belief.
To Apply
Please apply through our applicant tracking system, greenhouse
().
Please to apply.
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Keywords: NeuroTech X, Shoreline , Sr. Director, Translational Pharmacology, Executive , Seattle, Washington
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